Pseudocholinesterase activity in thyroid disease

Pseudocholinesterase activity in thyroid disease.

The present evidence indicates that serum pseudocholinesterase activity is increased to about 20% above the normal level in thyrotoxicosis and decreased by about 30% in myxoedema. Treatment restores the esterase level to the average mean activity of random normal as the patient becomes euthyroid. There is no evidence in the present investigation that any of the pseudocholinesterase variants mod...

Pseudocholinesterase activity in the central nervous system.

Pseudocholinesterase activity and atracurium v. suxamethonium block.

Serum pseudocholinesterase activity in pregnant women was assayed spectrophotometrically using either propionylthiocholine or suxamethonium as substrate. All patients had a normal phenotype as indicated by normal dibucaine and fluoride numbers. However, the mean cholinesterase activity was lower than in the general population. There was a negative correlation between cholinesterase activity and...

Pseudocholinesterase activity: determination and interpretation in pediatric anesthesia.

Pseudocholinesterase (PChE), also known as plasma cholinesterase, is a serine hydrolase capable of hydrolyzing esters including acetylcholine, succinylcholine, mivacurium and ester type local anesthetics such as procaine, chloroprocaine, tetracaine, cocaine and heroin. PChE is synthesized by the liver, and is found in the plasma, the pancreas, the heart and the brain. It has a serum half life o...

A peptidase activity exhibited by human serum pseudocholinesterase.

The identity of a peptidase activity with human serum pseudocholinesterase (PsChE) purified to apparent homogeneity was demonstrated by co-elution of both peptidase and PsChE activities from procainamide-Sepharose and concanavalin-A--Sepharose affinity chromatographic columns; comigration on polyacrylamide gel electrophoresis; co-elution on Sephadex G-200 gel filtration and coprecipitation at d...